Dec 6, - A study in Japan that compared eszopiclone (Lunesta) versus zolpidem (Ambien), for instance, found that at doses of 2mg or higher. They primarily help patients fall asleep more easily and stay asleep. The recommended dose for adults is 10 mg, taken once daily immediately before bedtime. While long-term intake of either Lunesta or Ambien has minor downsides like. Reviews and ratings for lunesta when used in the treatment of insomnia. But still no weird side effects, and sdly I still wake up more tired than I was with Lunesta, or So all in all a good experience and will likely ask for this instead of Ambien in Medical Marijuana is out of the question for me but has been recommended.