Mar 31, - Many things can make it difficult to fall asleep or stay asleep here and there. Lunesta and Ambien are two commonly prescribed drugs for short-term Your doctor will probably start you on a low dose to keep the side effects. Jan 30, - Learn the possible benefits, risks and side effects of prescription Sleeping pills may help when stress, travel or other disruptions keep you Eszopiclone (Lunesta), ✓, ✓, ✓ Zaleplon (Sonata), ✓, ✓. Zolpidem (Ambien, Edluar, Intermezzo, Zolpimist), ✓, ✓. Zolpidem extended release (Ambien CR), ✓, ✓, ✓. Sleeping problems that happen once or twice a month can be annoying, but Frequently, doctors have relied on sleep medications like eszopiclone (Lunesta and and generic); zaleplon (Sonata and generic); zolpidem (Ambien, Ambien CR, keep insomnia at bay longer than medication—even after the therapy ends.